The influence of Dad and tkv genes on dystrophin-deficient phenotype in Drosophila melanogaster
V. Rishko, O. Poberezhnyk, M. Kucherenko, N. Holub, D. Maksymiv, Ya. Chernyk
Ivan Franko National University of Lviv
4, Hrushevskyi St., Lviv 79005, Ukraine
yacher@mail.ru
Dad and tkv genes are involved in Dpp-signaling. To investigate these genes influence on dystrophin gene functioning in Drosophila melanogaster flies contained modificator gene and dystrophin gene inactivation construct in one organism were obtained. As a result of these hybrids screen it was shown resumption of wing vein structure, defects of which is the characteristic phenotype of dystrophin mutants. The penetrance of modyficator genes was 30,5–48,5% in the offspring of Dad and mutant lines crossing and 2–8% in individuals from tkv and mutant lines crossing. In addition it was shown partial restore of thoracic muscle structure in hybrid flies. It could be concluded that Dad gene manifested to be more active dystrophin-deficiency phenotype suppressor than tkv gene.
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Keywords: Drosophila, Dystrophin, gene-modificator
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