Effects of cadmium cations on lipid peroxidation and activity of enzymes of antioxidant system in leucocytes of animal blood
H. Antonyak*, L. Biletska**
*Ivan Franko National University of Lviv
41, Doroshenko St., Lviv 79000, Ukraine
**Lviv National Agrarian University
1, V.Velykyi St., Dublyany-Lviv 80381, Ukraine
The effects of prolonged administration (during 14 days) of cadmium chloride (3 mg/kg body weight) on intensity of lipid peroxidation and enzymes of antioxidant system in leucocytes of white rats were studied. It was established, that under an influence of cadmium the concentration of lipid peroxidation products (TBA-positive products) – were substantially increased in both the lymphocytes and neutrophilic granulocytes of animal blood. The activities of enzymes of antioxidant system in the leucocytes of rats changed in different ways during the experimental period, namely: catalase activity was diminished, and glutathione peroxidase activity was increased.
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Keywords: heavy metals, cadmium, leucocytes, lymphocytes, neutrophilic granulocytes, antioxidant system
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